Habitual coffee intake shapes the microbiome, modifies physiology and cognition
by scubakid on 4/24/2026, 4:04:42 AM
https://www.nature.com/articles/s41467-026-71264-8
Comments
by: testemailfordg2
Funded by the Institute for Scientific Information on Coffee (ISIC) — an industry body — which is a notable conflict of interest the authors disclose but don't extensively discuss
4/24/2026, 5:54:51 AM
by: TazeTSchnitzel
After habitually consuming caffeine (not in coffee form) daily, usually multiple times a day, for more than a decade, a horrible mental health incident happened to me that forced me to stop it for a while. Afterwards I didn't resume the habit, and so I no longer have a tolerance.<p>This has let me evaluate what caffeine does with fresh eyes, so to say, because I can now consume it occasionally while having many non-caffeinated days to compare to. It's a profoundly psychoactive substance and does a lot of things to cognition. I guess I have decided I don't enjoy how it feels, having previously been dependent on it.
4/24/2026, 6:50:34 AM
by: fedeb95
thirty-one participants were moderate coffee-drinkers (CD, i.e., people that usually consume between 3 to 5 cups of coffee per day).<p>3-5 is moderate? To me, 3 is already high.<p>Also, sample size is pretty low and they're all Irish.
4/24/2026, 7:52:05 AM
by: pinkmuffinere
I’m super interested in this sort of study! However, it looks like n=62 here, which I think weakens the results —they’re probably just useful as suggestions of possible effects. Also, any food is expected to have similar effects on the microbiome. They didn’t test caffeine in isolation. In some ways that’s better (I don’t consume caffeine in isolation), but in some ways that’s less useful (it’s possible you get similar results from many random vegetables)
4/24/2026, 5:13:37 AM
by: satvikpendem
What's cool is this effect exists even in decaf coffee, as someone who primarily drinks decaf black, for flavor and for a good night's rest as I'm sensitive to caffeine.
4/24/2026, 5:24:17 AM
by: ANarrativeApe
It would have been interesting to see if there was any difference relating to CYP1A2 (Cytochrome P450 1A2), the fast metabolizers and the slow metabolizers.
4/24/2026, 7:37:52 AM
by: reedf1
At least subjectively, coffee seems to help my memory. But maybe that's why I started drinking coffee?<p>I would probably drop coffee it was proven to have negative effects on memory.
4/24/2026, 5:07:59 AM
by: xingyi_dev
Whatever the case, a cup of coffee is basically what kickstarts my day.
4/24/2026, 9:08:05 AM
by: shinryuu
Would be real interesting to see a similar study on tea.
4/24/2026, 8:21:08 AM
by: wjnc
I have not much followed the science of gut microbiome and psychology. Is this really going where this article is pointing? That we can tease out causation in foods and habits via gut microbiome towards behavior and psychology? Pretty rad.
4/24/2026, 5:10:01 AM
by: getnormality
Coffee modifies physiology and cognition? You're telling me this for the first time.
4/24/2026, 5:03:43 AM
by: sdevonoes
I must be weird, but coffee (or caffeine) doesn’t really “wake me up” in the mornings and I could drink it in the night and still sleep well. Because of that I don’t drink coffee; I prefer tea
4/24/2026, 7:43:27 AM
by: therealdeal2020
good thing I have claude to summarize this and quickly realized that sample size was small and nothing much new unless you are a microbiome researcher
4/24/2026, 8:44:40 AM
by: poly2it
> ... reintroduction triggered acute microbiome changes independent of caffeine.<p>This sounds interesting. I've never really considered the constituents of coffee other than caffeine and what unique effects they may bring.<p>I wonder if I would experience behavioral effects if I replaced my coffee intake with caffeinated non-coffee drinks or pills?
4/24/2026, 5:12:54 AM
by: neya
The only good thing that keeps me from collapsing into a state of limbo is coffee and now, even that's bad (seems more like a mixed bag, but still)? Sigh.
4/24/2026, 5:01:43 AM
by: 6LLvveMx2koXfwn
"These findings reveal previously unrecognised effects of coffee on the microbiota–gut–brain axis, suggesting that microbiome profiles could potentially predict coffee consumption patterns", or, perhaps, just ask the patient?
4/24/2026, 5:08:05 AM